Carnosine in health and disease     

Guilherme Giannini Artioli  Craig Sale  Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.  相似文献   

The effect of exercise interventions on resting metabolic rate: A systematic review and meta-analysis     

Kristen MacKenzie-Shalders  Jaimon T. Kelly  Daniel So  Vernon G. Coffey  Nuala M. Byrne 《Journal of sports sciences》2020,38(14):1635-1649

ABSTRACT

The systematic review and meta-analysis evaluated the effect of aerobic, resistance and combined exercise on RMR (kCal·day^-1) and performed a methodological assessment of indirect calorimetry protocols within the included studies. Subgroup analyses included energy/diet restriction and body composition changes. Randomized control trials (RCTs), quasi – RCTs and cohort trials featuring a physical activity intervention of any form and duration excluding single exercise bouts were included. Participant exclusions included medical conditions impacting upon RMR, the elderly (≥65 years of age) or pregnant, lactating or post-menopausal women. The review was registered in the International Prospective Register of Systematic Reviews (CRD 42,017,058,503). 1669 articles were identified; 22 were included in the qualitative analysis and 18 were meta-analysed. Exercise interventions (aerobic and resistance exercise combined) did not increase resting metabolic rate (mean difference (MD): 74.6 kCal·day^-1[95% CI: ?13.01, 161.33], P = 0.10). While there was no effect of aerobic exercise on RMR (MD: 81.65 kCal·day^-1[95% CI: ?57.81, 221.10], P = 0.25), resistance exercise increased RMR compared to controls (MD: 96.17 kCal·day^-1[95% CI: 45.17, 147.16], P = 0.0002). This systematic review effectively synthesises the effect of exercise interventions on RMR in comparison to controls; despite heterogenous methodologies and high risk of bias within included studies.  相似文献   

现代远程教育对产业结构调整中利益联结因素的影响研究--基于从江县刚边乡三联村的实践应用案例     

孙飞 《贵州广播电视大学学报》2021,(1):8-13

近年来,国家对贫困地区产业发展支持力度极大,但政策的支持和产业的驻入却难以让贫困地区的扶贫产业落地生根,其中一个重要的原因是农户对产业的认知能力低和认同感缺失。如何从内因出发,激发农户的内生动力,文章尝试从贫困地区农户的认知认同和意识形态入手,结合现代远程教育手段,帮助贫困群众足不出户就能了解产业发展过程和前景,增强产业发展信心,变被动为主动。充分发挥现代远程教育对产业结构调整中利益联结因素潜移默化的作用,将思想扶贫、智慧扶贫与产业扶贫工作有机结合,“扶贫先扶智、治贫先治愚”,实现产业扶贫从“授人以鱼”向“授人以渔”的根本性跨越。  相似文献   

工业园区产业集聚评价方法研究——以新疆库车工业园区为例     

刘冠军 《科学学与科学技术管理》2016,(8):93-101

提高工业园区产业集聚水平对提高区域经济竞争力进而对新常态下我国经济保持中高速增长具有重要意义,而工业园区产业集聚水平的定量评价是其中一个基础性问题。首先将工业园区产业集聚的内涵解析为工业园区内所有企业之间具有密切产业联系的形态,然后分别基于产业生态学理论、经济学理论识别了工业园区内部企业之间由于物质流而形成的纵向产业联系、由于生产活动相同而形成的横向产业联系,并以两类产业联系数量占潜在产业联系数量的比例构建了工业园区产业集聚指数,以定量评价工业园区产业集聚水平。最后,以新疆库车工业园区为例进行了应用研究,表明构建的工业园区产业集聚指数具有可行性。构建的评价指数可为定量评价工业园区产业集聚水平进而促进工业园区产业集聚提供参考。  相似文献   

工业PC机的应用实例     

刘陆平 《科技广场》2006,(11):122-124

计算机控制系统的基础是工业控制计算机技术,其灵魂是智能控制技术。而工业控制计算机有巨型机、中型机和工业PC机,工业PC机是计算机控制技术的一个重要应用领域,本文对工业PC机应用现状进行了分析,并介绍了工业PC机的应用实例。  相似文献   

经济发展、产业结构调整与城镇建设用地规模控制   总被引：17，自引：0，他引：17  

陈利根  陈会广  曲福田  赵才水 《资源科学》2004,26(6):137-144

马鞍山市目前正处于城市产业结构调整及功能转型过程中.该研究以马鞍山市为例,通过统计描述、定性分析,系统地考察了人口城市化水平、经济发展水平、产业结构调整与城镇建设用地规模之间的关系,研究了在经济发展过程中如何合理确定和控制城镇建设用地规模的问题,并提出了一个待验证的假说.随后,用经济计量模型:Yi=α β1X1i β2X2i β3X3i εi验证了所提出的假说,并估计人口城市化水平、经济发展水平、产业结构调整等社会经济驱动力因子对城镇建设用地规模的影响.计量模型估计结果表明,城市化水平、经济发展水平与产业结构调整对城镇建设用地规模的影响具有不同的作用方向,城市化水平、经济发展水平带动了城市用地规模的扩张,而产业结构调整则有利于城市用地的集约化和用地结构的优化.研究结果验证了所提出的假说,其结论可以有力支持当前的城市产业结构调整以及功能转型政策,对其他的转型城市而言,也具有重要的借鉴意义.  相似文献   

工业锅炉集中监视与监控系统   总被引：1，自引：0，他引：1  

丁鹏飞 《中国科技信息》2005,(16):72

为了保证工业锅炉系统安全高效地运行,对工业锅炉进行了集中监视与控制。集中监视与控制系统由两级计算机组成。上位机是工业控制计算机,主要完成智能化的后台管理和实时显示运行信息等功能,下位机是可编程控制器,主要完成现场信号和数据的采集及实时控制。该系统为工业锅炉高效安全生产提供了可靠的保障。  相似文献   

Can creative destruction be destroyed? Military IR&D and destruction along the value-added chain     

Allen Kaufman  Mark Brumer 《Research Policy》2003,32(9):1537-1554

We elaborate a supply chain innovation matrix that can be applied to both commercial and military supply chains. By shifting the analysis from a focal firm to industry structure, we argue that the market structure of the entire supply chain functions as a major moderating variable in determining both the timing and adoption of innovations, both for commercial and military markets. We extend work on supply chain resource dependency by drawing a distinction between market-structure-induced resource dependency and supplier over-reliance on a customer in a competitive market. This has policy implications for the organization of military industrial research and development (IR&D). Joint service research and development (Jointness) will certainly bring about innovation, but it will be incremental, reinforcing established military hierarchies. Policy makers may need to add this probable consequence when comparing Jointness and inter-service rivalry. The cost savings inherent in Jointness may unwittingly sustain a military force unready for fighting the next war.  相似文献   

Research parks and the location of industrial research laboratories: an analysis of the effectiveness of a policy intervention     

Stephen J Appold 《Research Policy》2004,33(2):225-243

Utilizing county-level data, this paper predicts the growth in the number of private industrial research laboratories between 1960 and 1985. This was a period of rapid growth and spatial reorganization in industrial research activity. A multi-equation model which allows the influence of unmeasured factors and selectivity to be taken into account is used to test the ability of a policy intervention, research parks, to affect the growth in the number of local laboratories. Although the presence of research parks is correlated with the number of laboratories, the analysis indicates that research parks were not effective local development tools but instead benefitted from the growth of research activity.  相似文献   

人牙及骨组织中稀土分布状态的研究   总被引：1，自引：0，他引：1  

程发良  钟广涛 《科技通报》1994,10(6):380-382

测定了人体骨胳、牙齿中的稀土含量，考察了牙齿作为研究人体稀土代谢状况样品的可行性，研究了微量稀土元素在人牙、骨中的分布状态，提出了稀土在人体不同部位骨胳中分布的可能机制。  相似文献